Role of bone morphogenetic proteins in cardiac differentiation

B VANWIJK, A MOORMAN, M VANDENHOFF
2007 Cardiovascular Research  
Bone morphogenetic proteins (BMP) are involved in the regulation of a plethora of processes underlying cardiovascular development. This review summarizes the effects of BMP and the signaling pathways that regulate the differentiation of cardiomyocytes from mesoderm in the heart-forming region and at the distal borders of the heart tube from the second heart field. Subsequently, the role of BMPs in the formation of the ventricular chambers and septovalvulogenesis in the atrioventricular canal
more » ... entricular canal and outflow tract is described. Finally, the effects of BMPs in stem cell biology and cardiac regeneration are discussed.
doi:10.1016/j.cardiores.2006.11.022 pmid:17187766 fatcat:sf3nzb33bbg7tbsp7fsgt3kgeu