The goal of the present study was to evaluate the antibacterial and antifungal of the crude extract/fractions of Crataegus songarica against six bacterial and fungal strains. The extract/fractions demonstrated significant susceptibility against tested bacteria namely Escherchia coli, Bacillus subtilis and Shigella flexeneri illustrated the most susceptibility were with MICs 150 µg/mL, 390 µg/mL and 220 µg/mL respectively. Meanwhile Antifungal activity was also recorded table and the crude

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... t and fractions showed marked activity against Trichophyton longifusus, Aspergillus flavus, Microspoum canis and Fusarium solani with MICs 220 µg/mL, 180 µg/mL, 110 µg/mL and 160 µg/mL respectively. Based on the obtained results, C. songarica could be considered a new natural healing agent for the treatment of various infectious diseases.