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Hyperlipidemia Promotes Osteoclastic Potential of Bone Marrow Cells Ex Vivo
Arteriosclerosis, Thrombosis and Vascular Biology
Objectives-Osteoporosis is associated epidemiologically with atherosclerosis and hyperlipidemia. We previously found that atherogenic lipids regulate bone formation. To determine whether hyperlipidemia also affects bone resorption, we compared osteoclastogenesis in marrow preosteoclasts derived from hyperlipidemic versus control mice. Methods-Nonadherent marrow cells from low-density lipoprotein receptorϪ/Ϫ (LDLRϪ/Ϫ)and C57BL/6J mice were cultured with M-CSF and ligand for receptor activator ofdoi:10.1161/01.atv.0000112023.62695.7f pmid:14670933 fatcat:w7vbozdklrd2bjsgsufbqhzfhy