Apoptotic Molecular Advances in Breast Cancer Management [chapter]

Pontsho Moela, Lesetja R. Motadi
2015 Cell Death - Autophagy, Apoptosis and Necrosis  
Breast cancer is the most common cancer type amongst women, accounting for most female cancer deaths second to cervical cancer worldwide. It is, therefore, highly crucial to understand the molecular biology and explore other pathways involved in carcinogenesis in order to select appropriate treatment not only for breast cancer but for other cancers as well. Cancer progression is favoured by DNA damage and in most cases a consequent disruption of the apoptotic pathway, thus leading to
more » ... ading to uncontrolled cell proliferation. Therefore, current therapeutic strategies aim at targeting the apoptotic pathways in order to combat cancer. In this manuscript, we discuss the ways in which evasion of apoptosis during carcinogenesis occurs and the types of current therapeutic strategies as well as promising future approaches against breast cancer.
doi:10.5772/61654 fatcat:g4ywwyx35nbtxgg52nfedg4gnq