The widely used procedure of estimating postoperative cup orientation based on a single standard AP X-ray radiograph is known inaccurate, largely due to the wide variability in individual pelvic orientation relative to X-ray plate. CT-based 2D/3D rigid image registration methods have been developed to measure post-operative cup orientation. Although encouraging results have been reported, their extensive usage in clinical routine is still limited. This may be explained by their requirement of

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... ving a CT study of the patient at some point during treatment, which is not available for vast majority of Total Hip Arthroplasty procedures performed nowadays. To address this limitation, this article proposes a statistically deformable 2D/3D registration approach for estimating post-operative cup orientation. No CT study of the patient is required any more. Compared to ground truths established from post-operative CT images, the cup orientations measured by the present technique in a cadaver experiment showed differences of 1.7 ± 1.4°for anteversion and difference of 1.5 ± 1.5°for inclination. When the present technique was evaluated on patients' datasets, differences of 2.2 ± 1.3°and differences of 2.0 ± 0.8°were found for the anteversion and the inclination, respectively. The experimental results, though still preliminary, demonstrated the efficacy of the present approach.