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Role of SIRPα in Homeostatic Regulation of T Cells and Fibroblastic Reticular Cells in the Spleen
Kobe J. Med. Sci
Signal regulatory protein α (SIRPα), is an immunoglobulin superfamily protein that is predominantly expressed in macrophages and dendritic cells (DCs), especially CD4 + conventional DCs (cDCs). In this study, we demonstrated that, in addition to the reduced number of CD4 + cDCs, the number of T cells was significantly decreased in the spleen of Sirpa-/-mice, in which full-length of SIRPα protein was systemically ablated. The size of the T cell zone was markedly reduced in the spleen offatcat:4mm5eet2avcczjastkj4yg3ewy