Fluctuation theorem and large deviation function for a solvable model of a molecular motor

D. Lacoste, A. W.C. Lau, K. Mallick
2008 Physical Review E  
We study a discrete stochastic model of a molecular motor. This discrete model can be viewed as a minimal ratchet model. We extend our previous work on this model, by further investigating the constraints imposed by the Fluctuation Theorem on the operation of a molecular motor far from equilibrium. In this work, we show the connections between different formulations of the Fluctuation Theorem. One formulation concerns the generating function of the currents while another one concerns the
more » ... onding large deviation function, which we have calculated exactly for this model. A third formulation of FT concerns the ratio of the probability of making one forward step to the probability of making one backward step. The predictions of this last formulation of the Fluctuation Theorem adapted to our model are in very good agreement with the data of Carter and Cross [Nature, 435, 308 (2005)] on single molecule measurements with kinesin. Finally, we show that all the formulations of FT can be understood from the notion of entropy production.
doi:10.1103/physreve.78.011915 pmid:18763990 fatcat:42xsabvpznc5dflnvnlmjgrra4