The study describes development of a stability indicating RP-HPLC-PDA method for the estimation of Oxcarbazepine in bulk form with the mobile phase compatible to LC-MS analysis. The proposed method utilizes a Phenomenex C 18 column (150 mm x 4.6 mm, 5.0 µ particle size), at ambient temperature, optimum mobile phase consisted of methanol: formic acid (0.02%) in the ratio of 50:50 (v/v). The flow rate was optimized to 1mL/min and the detection was carried at 229 nm. The drug substance was exposed

more »

... to hydrolytic, oxidative, thermal and photolytic stress conditions, and the resultant samples were analysed by the proposed method.