Synergism between methamphetamine and alcohol in a case of methamphetamine psychosis

SHINICHIRO HARAJIRI, HIDEKI KOJIMA, KATSUYOSHI ARIKAWA, CHISHIN MIURA, KAZUTOYO INANAGA
1986 The Kurume Medical Journal  
The case of a 25-year-old male with methamphetamine dependence indicating the presence of synergism between methamphetamine and alcohol was reported. The three clinical features observed in the present case were: First, ingesting large quantities of alcohol after an intravenous injection of the psychostimulant induced psychomotor excitement, indicating that alcohol itself could potentiate the psychosis-inducing action of the psychostimulant. Second, repetition of the alcohol intake without the
more » ... rug injection reactivated a psychotic state, suggesting that there is a cross-reverse tolerance phenomenon to alcohol. Third, drug injection alone, twice aggavated the psychiatric symptoms, indicating the presence of reverse tolerance to the psychostimulant.
doi:10.2739/kurumemedj.33.163 fatcat:ukw6r2q5pbenlhklmonqwwudcu