In this paper purpose is investigate protective effects of GUF (Glycyrrhiza uralensis Fischer) Extract in Water Immersion Restrain Stress (WIRS) induced Gastric injury rat model. 30 min after GUF orally administered in rat, implemented water immersion during 8 hr. studying animal groups are as follows; Group Ⅰ : Control group(n=5), group Ⅱ : WIRS induced Rat, GroupⅢ: WIRS induced + GUF Extract 25mg/kg treated Rat, GroupⅣ: WIRS induced + GUF Extract 50mg/kg treated Rat, GroupⅤ: WIRS induced +

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... Extract 100mg/kg treated Rat. We confirmed gastric injury through stomachs were opened along the greater curvature and gastric lesion area was quantified by pixel density using digital camera and we experimented western blotting for investigate inflammation related signal transduction protein expression differences in Liver. Researcher result showed oral administration of GUF Extracts has dose dependent protective effects in gastric injury and suggested having improvement effect of inflammation.