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CHRONIC LYMPHOCYTIC LEUKEMIA
1956
A M A Archives of Internal Medicine
Preserved Fulltext
Karyotype complexity and VH gene status in B-cell chronic lymphocytic leukemia B-cell chronic lymphocytic leukemia-related genomic changes were analyzed by karyotyping, fluorescence in situ hybridization, and VH gene sequencing in a prospective clinical evaluation. The VH mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for specific VH gene usage (V3-21 and V1-69) . Complex karyotypes were highly indicative of disease progression.
doi:10.1001/archinte.1956.00250240169020
pmid:13312727
fatcat:mojamhdthvci3dnlj3xe626pwq