Effect of occupational air pollutants on various histological types of lung cancer: a population based case-control study

H Becher, W Jedrychowski, J Wahrendorf, Z Basa-Cierpialek, E Flak, K Gomola
1993 Occupational and Environmental Medicine  
A population based case-control study was performe4 in Cracowr, Poland, to determine the effect of occupational air pollutants on various histological types of lung cancer. Male cases and controls were identified from the Cracow Death Register. Information was obtained by mailed questionnaire from next of kin on smoking, occupational branch, occupational exposures, and other pertinent variables. Response rates were 73-5% in cases and 72-0% in controls. For cases that underwent a bronchial
more » ... t a bronchial biopsy or surgical excision the histological diagnosis of the tumour was obtained from clinical records. The case group contained 343 subjects with squamous cell carcinomas, 151 with small cell carcinomas, and 106 with adenocarcinomas. Twenty seven cases showed other histological types (large cell carcinoma and not classifiable). Analysis was performed separately by histological type for occupational exposure variables adjusted for smoking. Long term exposure to mineral dust and metal dust (20 years or more) was found to be a significant risk factor for small cell and squamous cell carcinoma. The effect was more pronounced if the analysis was restricted to those aged less than 70 years. The highest relative risk (RR) due to occupational exposures was found for squamous cell carcinoma and exposure to mineral dust for more than 20 years (RR=2-45, 95% CI 1-43-4-19). The estimated effect of mineral dust on small cell carcinoma and adenocarcinoma was smaller (RR=2-29, 95% CI 1 164-453 and RR=2 04, 95% CI 0-89-4-64 respectively). The effect of metal on 23 July 2018 by guest. Protected by copyright. http://oem.bmj.com/ Br J Ind Med: first published as 10.1136/oem.50.2.136 on 1 February 1993. Downloaded from Effect of occupational air pollutants on various histological types of lung cancer: a population based case-control study on 23 July 2018 by guest. Protected by copyright. http://oem.bmj.com/ Br J Ind Med: first published as 10.1136/oem.50.2.136 on 1 February 1993. Downloaded from Effect of occupational air pollutants on various histological types of lung cancer: a population based case-control study on 23 July 2018 by guest. Protected by copyright. http://oem.bmj.com/ Br J Ind Med: first published as 10.1136/oem.50.2.136 on 1 February 1993. Downloaded from Effect of occupational air pollutants on various histological types of lung cancer: a population based case-control study
doi:10.1136/oem.50.2.136 fatcat:2sschw54angpfg6g7p4ubzzeli