Objective: To determine the frequency of H. pylori detection in dyspeptic patients and its association with gastro-duodenal pathologies confirmed on histology. Study Design: A Retrospective Study. Place and Duration: In the Gastroenterology Department of Holy Family Hospital, Rawalpindi for one year duration from June 2017 to June 2018. Methods: Upper GI endoscopy was performed in 100 adult cases with sequential dyspepsia. For histology, biopsy was taken from Antral part of stomach. If

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... was positive, the infection with H. pylori was confirmed. Results: Of the 100 subjects, 43 (43%) were male and 57 (57%) were female. The 26-67 years was the age range and the mean age was 37 ± 14.5 years. 71 patients (71%) were diagnosed with H. pylori. Gastritis was the most common finding on endoscopy (83%), severe gastro-duodenal pathology (duodenal ulcer, gastric cancer and gastric ulcer) seen in 11 (11%) patients only. Conclusion: The H. pylori prevalence is high in dyspeptic patients. Using biopsy based methods in the patients presented at Medicine OPD, it is necessary to evaluate and treat H. pylori infection. Key words: Dyspepsia, H. pylori, antral biopsy.