Frontal preparatory neural oscillations associated with cognitive control: A developmental study comparing young adults and adolescents

Kai Hwang, Avniel S. Ghuman, Dara S. Manoach, Stephanie R. Jones, Beatriz Luna
2016 NeuroImage  
Functional magnetic resonance imaging (fMRI) studies suggest that age-related changes in the frontal cortex may underlie developmental improvements in cognitive control. In the present study we used magnetoencephalography (MEG) to identify frontal oscillatory neurodynamics that support age-related improvements in cognitive control during adolescence. We characterized the differences in neural oscillations in adolescents and adults during the preparation to suppress a prepotent saccade
more » ... de trials -AS) compared to preparing to generate a more automatic saccade (prosaccade trials -PS). We found that for adults, AS were associated with increased beta-band (16-38 Hz) power in the dorsal lateral prefrontal cortex (DLPFC), enhanced alpha-to low beta-band (10-18 Hz) power in the frontal eye field (FEF) that predicted performance, and increased cross-frequency alpha-beta (10-26 Hz) amplitude coupling between the DLPFC and the FEF. Developmental comparisons between adults and adolescents revealed similar engagement of DLPFC beta-band power but weaker FEF alpha-band power, and lower cross-frequency coupling between the DLPFC and the FEF in adolescents. These results suggest that lateral prefrontal neural activity associated with cognitive control is adult-like by adolescence; the development of cognitive control from adolescence to adulthood is instead associated with increases in prefrontal connectivity and strengthening of inhibition signaling for suppressing task-incompatible processes.
doi:10.1016/j.neuroimage.2016.05.017 pmid:27173759 pmcid:PMC4914451 fatcat:d7rlodhon5aizbetczucepkahy