Assessment of Anticoccidial Efficacy of Novel Triazine Compound and Sulfaclozine against Experimentally Induced Caecal Coccidiosis in Broiler Chickens

Dina Hagag, Kamal El-Shazly, Magdy Abd El-Aziz, Amira Abd El-Latif, Hanem El Sharkaway, Walied Abdo, Mohamed Barakat
2020 Sains Malaysiana  
This study was performed to investigate the theraputic efficacy of toltrazuril, sulfaclozine sodium and their combination in broiler chicken for the treatment of experimentally induced caecal coccidiosis. For this purpose, seventy-five day-old chicks were randomly divided into five equal groups (15 each). G 1 , kept as control negative; G 2 , infected non treated (control positive); G 3 , infected treated with toltrazuril (1 mL/L); G 4 , infected treated with sodium sulfaclozine (2 mL/L); G 5 ,
more » ... ine (2 mL/L); G 5 , infected treated with toltrazuril (1 mL/L) + sulfaclozine Na (2 g/L). All groups except negative control group were inoculated orally with 5 × 10 4 sporulated oocysts of Eimeria tenella (field isolate) on the day 15 th of age. According to the present results, G 2 showed a significant increase in oocyst count, AST, ALT, ALP, uric acid, and creatinine, with significant decrease in body weight gain, hematological parameters, total protein, and albumin. Treatment decreased the harmful effect of infection but some significant differences were shown between infected and treated groups and non infected and non treated group in assessment criteria. Furthermore, the histopathological findings were also discussed. In conclusion, the current study showed that the application of both tested drugs gave significant and satisfactory improvement in the assessment criteria as well as they are effective in control of coccidiosis caused by Eimeria tenella. ABSTRAK Kajian ini dilakukan untuk mengkaji keberkesanan terapeutik toltrazuril, natrium sulfaklozina dan gabungannya pada ayam pedaging untuk rawatan terhadap koksidiosis sekum teraruh uji kaji. Bagi tujuan ini, anak ayam berusia tujuh puluh lima hari dibahagikan secara rawak masing-masing kepada lima kumpulan yang sama (15 kumpulan). G 1 , sebagai kawalan negatif; G 2 , dijangkiti dan tidak dirawat (kawalan positif); G 3 , dijangkiti dan dirawat dengan toltrazuril (1 mL/L); G 4 , dijangkiti dan dirawat dengan natrium sulfaklozina (2 g/L); G 5 , dijangkiti dan dirawat dengan toltrazuril (1 mL/L) + natrium sulfaklozina (2 g/L). Semua kumpulan kecuali kumpulan kawalan negatif disuntik secara lisan dengan 5 × 10 4 oosista sporulasi bagi Eimeria tenella (medan terasing) pada hari ke-15. Hasilnya, G 2 menunjukkan peningkatan yang signifikan dalam jumlah oosistacre, AST, ALT, ALP, asid urik dan kreatinin, dengan penurunan yang signifikan dalam kenaikan berat badan, parameter hematologi, jumlah protein dan albumin. Rawatan telah mengurangkan kesan berbahaya disebabkan jangkitan tetapi beberapa perbezaan ketara ditunjukkan antara kumpulan yang dijangkiti dan dirawat dan kumpulan yang tidak dijangkiti dan tidak dirawat dalam kriteria penilaian. Tambahan pula, penemuan histopatologi juga dibincangkan. Kesimpulannya, kajian semasa menunjukkan bahawa penggunaan kedua-dua ubat yang diuji memberikan peningkatan yang ketara dan memuaskan dalam kriteria penilaian serta berkesan juga dalam mengendalikan koksidiosis yang disebabkan oleh Eimeria tenella.
doi:10.17576/jsm-2020-4911-03 fatcat:mzga252a2ff77plzolbmriobe4