INTERNATIONAL JOURNAL OF PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL SCIENCES A STUDY ON THE EFFECT OF MILLET AND PULSE BASED PASTA ON BLOOD GLUCOSE AND LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC RATS
The study of pasta having antidiabetic and hypolipidemic properties gives a new approach in the treatment of diabetes mellitus. The study was carried out to evaluate the antidiabetic and hypolipidemic effect of millet and pulse incorporated pasta (noodles) in alloxan-induced diabetic albino rats. The rats were divided into 7 groups of 6 animals each. Group I served as non-diabetic control, Group II as diabetic control and Groups III as treatment control group, while Groups IV, V, VI and VII
... , V, VI and VII served as treatment groups. Diabetes was induced in Group II rats by administration of alloxan monohydrate (150 mg/kg) through the intraperitoneal route, whereas all the treatment groups (including Group III) received millet and pulse incorporated pasta (100 mg/kg body weight). After 28 days of treatment body weight, blood glucose, haemoglobin, glycosylated haemoglobin, plasma insulin and lipid profile were determined. All the values are expressed as Mean ± SEM. The data were analyzed using analysis of variance (ANOVA) and the group means were compared by Newman-Keuls multiple range test (NKMRT). Values were considered statistically significant at p<0.01. The alloxan-induced diabetic rats given millet and pulse incorporated pasta at the dose of 100 mg/kg body weight showed highly significant reduction in blood glucose and serum lipid profile levels. It is concluded that millet and pulse incorporated noodles is effective in controlling blood glucose levels and improving lipid profile in diabetic rats.