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Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects
2013
International Journal of Oncology
SIRT1 and SIRT2 are deacetylase enzymes that belong to the sirtuin family and are involved in tumorigenesis. In our screen for small molecules inhibiting SIRT1/2 toxoflavin was identified. Toxoflavin potently inhibited SIRT1 activity in in vitro deacetylase assay using purified SIRT1 protein. SIRT2 activity was also inhibited by toxoflavin less potently than SIRT1 in deacetylase assay in vitro. Toxoflavin exhibited growth inhibition of various cancer cell lines including A549 lung cancer cells
doi:10.3892/ijo.2013.2035
pmid:23900402
fatcat:tofd2vz5dbhjhgunm3sk6ivvbq