Rapid progressive anti-GBM glomerulonephritis with multiple auto-antibodies

David Micarelli, Teresa Valentina Ranalli, Anna Rita Taddei, Angela Solazzo, Francesca Moccia, Sandro Feriozzi
2020 Journal of Nephropathology  
Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by progressive loss of renal function in a short period. At renal biopsy, it is characterized by crescent formation. RPGN may be associated with the presence of circulating antibodies. We report a case of type IV RPGN [ANCA and Anti–glomerular basement membrane (anti-GBM) antibody disease], a severe disease causing a difficult to treat picture. Our case was complicated by severe thrombocytopenia due to the use of
more » ... ue to the use of heparin and later on by thrombotic microangiopathy. These events occurred rapidly, making the clinical framing and management decisions very hard.
doi:10.34172/jnp.2020.30 fatcat:yfpp7s76yje3dm6c7thh66gh2y