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Adverse Bioenergetic Consequences of Na+-Ca2+ Exchanger-Mediated Ca2+ Influx in Cardiac Myocytes
2010
Circulation
Background-In heart failure, the Na ϩ -Ca 2ϩ exchanger (NCX) is upregulated and mediates Ca 2ϩ influx (instead of efflux) during the cardiac action potential. Although this partly compensates for impaired sarcoplasmic reticulum Ca 2ϩ release and supports inotropy, the energetic consequences have never been considered. Because NCX-mediated Ca 2ϩ influx is rather slow and mitochondrial Ca 2ϩ uptake (which stimulates NADH production by the Krebs cycle) is thought to be facilitated by high Ca 2ϩ
doi:10.1161/circulationaha.110.968057
pmid:21098439
fatcat:4dgxemnrongjxor7ww73xg3uuy