Effect of Extract Containing Metabolic Products of Bacillus Subtilis Natto on Hypertension in SHR and SHR-SP Rats
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
We investigated the preventive effect of extract containing metabolic products of Bacillus subtilis natto (NFE extract) on essential hypertension. The spontaneously hypertensive rat (SHR rat) and stroke-prone SHR rat (SHR-SP rat) were used in this study, and the NFE extract was administered by free drinking for 6-14 weeks of age (6, 7 weeks of age, 25 mL/day/rat; 8-14 weeks of age, 30 mL/day/rat). The administration of NFE extract did not affect the food intake and body weight in the WKY, SHR
... t in the WKY, SHR and SHR-SP rats. Significant changes in systolic (SBP) and diastolic (DBP) blood pressure levels between WKY rats administered with and without NFE extract were not observed for rats 6-14 weeks of age. On the other hand, the SBP and DBP in SHR and SHR-SP rats increased with aging, and the administration of NFE extract significantly attenuated the increased SBP, DBP in SHR and SHR-SP rats. In conclusion, the administration of NFE extract prevents increased blood pressure in SHR and SHR-SP rats. These findings provide significant information that can be used to design further studies aimed at elucidating the precise mechanism for decrease of blood pressure by NFE extract.