Fatty Liver is Associated with Low N-terminal pro-B-type Natriuretic Peptide in a Healthy Population: From the Kangbuk Samsung Health Study [post]

Hyo-In Choi, Mi Yeon Lee, Byeong Kil Oh, Seung Jae Lee, Jeong Gyu Kang, Sung Ho Lee, Jong-Young Lee, Byung Jin Kim, Bum Soo Kim, Jin Ho Kang, Ki Chul Sung
2021 unpublished
BackgroundFatty liver (FL), insulin resistance (IR), and obesity often coexist, but data on the independent impacts of these factors on N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in healthy populations are scarce. We therefore examined the impact of FL, IR and obesity on NT-proBNP levels using a large set of cross-sectional data.MethodsThe associations of FL, IR and obesity with NT-proBNP were analyzed in 39,923 healthy adult participants using Kangbuk Samsung Health Study
more » ... . IR was estimated using homeostasis model assessment-estimated insulin resistance (HOMA-IR) index. A multivariable regression model that adjusted for factors that influence NT-proBNP was conducted to identify associations between NT-proBNP and FL on abdominal ultrasound. ResultsA total of 11,704 (29.3%) individuals had FL on abdominal ultrasound. FL, IR and obesity showed independent inverse associations with NT-proBNP after multiple adjustments for baseline characteristics. In a multivariable regression model adjusting for IR and obesity, FL was independently associated with lower levels of NT-proBNP (odds ratio 0.864, 0.849 - 0.880). The combination of FL and IR was a powerful dual predictor, lowering NT-proBNP levels approximately 25% in the generally healthy study population.ConclusionIn this large sample of healthy individuals, FL was independently associated with lower NT-proBNP levels. FL and a high HOMA-IR index are a powerful predictor combination for lower NT-proBNP levels. Further research is needed to elucidate the mechanism underlying the association between FL and NT-proBNP.
doi:10.21203/rs.3.rs-139845/v1 fatcat:dzgqmu53mffohc44w24yetx6hm