The World Health Organization estimates that infertility concerns nearly 190 million people worldwide. Male associated factors are found up to 50% of the cases. This study aimed to investigate the effects of vitamin and antioxidant supplementation on semen parameters and pregnancy rates. Methods: We report a prospective study comparing sperm parameters before and after micronutrient treatment in 52 infertile male patients. The duration of the study was 15 months. The primary outcomes were the

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... olution of sperm parameters after treatment intake. The secondary outcomes were pregnancy rates. Wilcoxon Signed Rank test was used for statistical analysis. Results: The mean age was 36.2 years. Primary Infertility was reported in 35 cases (71.1%). Varicocele was reported in 12 patients (23%). Infertility remained idiopathic in 18 cases (34.6%). Before treatment, the mean sperm concentration was 39.3 10 6 /ml (0.35-290). The mean progressive motility was 34.3 % (3-76%). The mean typical morphology was 3.6% (1-17%). After treatment, the mean sperm concentration was 39.6 10 6 /ml (1.4-240); the mean progressive motility was 36.2% (7-78%); the mean typical morphology was 3.5% (1-13%). The main variations of the semen observed after treatment were an improvement of the sperm concentration in 55.8% and of the progressive motility in 51.9%. Sixteen pregnancies (30.7%) were obtained. Five pregnancies (9.6%) were spontaneous and 11 (21.1%) occurred after assisted reproductive techniques (3 after IVF-ICSI and 8 after intra uterine insemination). Conclusion: The results of this study are in favour of the positive effects of nutraceuticals and antioxidants on semen parameters and pregnancy rates. Temime RB (2020) Variation of sperm parameters after metabolic and antioxidant supplementation in infertility patients with Oligoasthenoteratospermia (Sperm parameters and antioxidants) Volume 7: 2-6