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Oxidation of Hepatic Carnitine Palmitoyl Transferase-I (CPT-I) Impairs Fatty Acid Beta-Oxidation in Rats Fed a Methionine-Choline Deficient Diet
2011
PLoS ONE
There is growing evidence that mitochondrial dysfunction, and more specifically fatty acid b-oxidation impairment, is involved in the pathophysiology of non-alcoholic steatohepatitis (NASH). The goal of the present study was to achieve more understanding on the modification/s of carnitinepalmitoyltransferase-I (CPT-I), the rate-limiting enzyme of the mitochondrial fatty acid b-oxidation, during steatohepatitis. A high fat/methionine-choline deficient (MCD) diet, administered for 4 weeks, was
doi:10.1371/journal.pone.0024084
pmid:21909411
pmcid:PMC3164715
fatcat:ixq5wi7cjrfqrn654zcu6xuapi