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Protein-protein interaction networks: probing disease mechanisms using model systems
2013
Genome Medicine
Protein-protein interactions (PPIs) and multi-protein complexes perform central roles in the cellular systems of all living organisms. In humans, disruptions of the normal patterns of PPIs and protein complexes can be causative or indicative of a disease state. Recent developments in the biological applications of mass spectrometry (MS)-based proteomics have expanded the horizon for the application of systematic large-scale mapping of physical interactions to probe disease mechanisms. In this
doi:10.1186/gm441
pmid:23635424
pmcid:PMC3706760
fatcat:62p2wi4mqzfudlr73lasftwb2q