Protein-protein interaction networks: probing disease mechanisms using model systems

Uros Kuzmanov, Andrew Emili
2013 Genome Medicine  
Protein-protein interactions (PPIs) and multi-protein complexes perform central roles in the cellular systems of all living organisms. In humans, disruptions of the normal patterns of PPIs and protein complexes can be causative or indicative of a disease state. Recent developments in the biological applications of mass spectrometry (MS)-based proteomics have expanded the horizon for the application of systematic large-scale mapping of physical interactions to probe disease mechanisms. In this
more » ... view, we examine the application of MS-based approaches for the experimental analysis of PPI networks and protein complexes, focusing on the diff erent model systems (including human cells) used to study the molecular basis of common diseases such as cancer, cardiomyopathies, diabetes, microbial infections, and genetic and neurodegenerative disorders.
doi:10.1186/gm441 pmid:23635424 pmcid:PMC3706760 fatcat:62p2wi4mqzfudlr73lasftwb2q