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Rapid ventricular pacing in the dog: pathophysiologic studies of heart failure
1986
Circulation
We examined rapid ventricular cardiac pacing as a means of inducing heart failure in the dog to establish the sequence and nature of physiologic compensation in this preparation. Seven animals paced at 250 beats/min for 3 weeks (VP8 group) showed an increase in cardiac size from 78.5 + 9.5(SD) to 105.8 ± 13.0 cm2, a reduction in mean arterial pressure from 149 ± 7 to 130 ± 21 mm Hg, a fall in cardiac index from 196 ± 57 to 125 ± 37 ml/kg/min, and an increase in left ventricular filling pressure
doi:10.1161/01.cir.74.5.1075
pmid:2945673
fatcat:ug2iktmcsvgznm4livohyysssi