Abstract— Keratoconus is a progressive asymmetrical, bilateral, non-inflammatory corneal ectasia casing refractive errors. Various techniques are used to manage these cases. Corneal collagen cross linking (accelerated method) is one of such technique. A hospital based follow up study was conducted on 30 Keratoconus patients to find out the effect of corneal collagen cross linking (accelerated method) on refractive variables of Keratoconus patients. After this procedure, there was improvement in

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... Best Corrected Visual Acuity 0.382, decrease in Cylindrical Refractive Power at 0.73%, decrease in Spherical Refractive Power at 19.32%, decrease in Spherical Equivalent at -6.15%, decrease KMAX of 0.712%, decline Mean Irregularity of 9.09%, Corneal thickness (Thinnest Point) decreased by 3.48%, Anterior Best Fitted Sphere Values decreased by 1.49% and Posterior Best Fitted Sphere decreased by 1.16%. It can be concluded from this present study that there is a significant improvement in topographic corneal changes and refractive results in patients with corneal ectasia after C3R. These results can illustrate the efficacy and usage of CXL for keratoconus among Indian patients. However, more studies and clinical trials are required to establish definite conclusions on the efficacy of C3R.