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Pax6Modulates the Dorsoventral Patterning of the Mammalian Telencephalon
2000
Journal of Neuroscience
The Pax6 gene encodes a transcription factor with a restricted expression in the ventricular zone of the pallium and subpallium. We tested whether the function of Pax6 is necessary for the correct patterning and morphogenesis of the vertebrate telencephalon. Homozygous embryos of the Pax6/Small eye mutant lack functional PAX6 protein because of a point mutation of the gene. In the mutant Small eye embryos we detected a ventralization of the molecular patterning of the telencephalon at two
doi:10.1523/jneurosci.20-21-08042.2000
pmid:11050125
fatcat:gu2cgacs3rekrja3hcwdybptwe