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Phosphorylation of Chemoattractant Receptors Is Not Essential for Chemotaxis or Termination of G-protein-mediated Responses
Journal of Biological Chemistry
In several G-protein-coupled signaling systems, ligandinduced receptor phosphorylation by specific kinases is suggested to lead to desensitization via mechanisms including receptor/G-protein uncoupling, receptor internalization, and receptor down-regulation. We report here that elimination of phosphorylation of a chemoattractant receptor of Dictyostelium, either by site-directed substitution of the serines or by truncation of the C-terminal cytoplasmic domain, completely preventeddoi:10.1074/jbc.272.43.27313 pmid:9341180 fatcat:kgxwq4ab5vcu3he3qpiv4yuzfy