Transcriptional Mechanisms Underlying Sensitization of Peripheral Sensory Neurons by Granulocyte-/Granulocyte-Macrophage Colony Stimulating Factors

Kiran Kumar Bali, Varun Venkataramani, Venkata P Satagopam, Pooja Gupta, Reinhard Schneider, Rohini Kuner
2013 Molecular Pain  
Cancer-associated pain is a major cause of poor quality of life in cancer patients and is frequently resistant to conventional therapy. Recent studies indicate that some hematopoietic growth factors, namely granulocyte macrophage colony stimulating factor (GMCSF) and granulocyte colony stimulating factor (GCSF), are abundantly released in the tumor microenvironment and play a key role in regulating tumor-nerve interactions and tumor-associated pain by activating receptors on dorsal root
more » ... (DRG) neurons. Moreover, these hematopoietic factors have been highly implicated in postsurgical pain, inflammatory pain and osteoarthritic pain. However, the molecular mechanisms via which G-/GMCSF bring about nociceptive sensitization and elicit pain are not known.
doi:10.1186/1744-8069-9-48 pmid:24067145 pmcid:PMC3852053 fatcat:zsn6xyd6ofhahcmh2ba75pujty