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mir15a/mir16‐1 cluster and its novel targeting molecules negatively regulate cardiac hypertrophy
2020
Clinical and Translational Medicine
In response to pathological stimuli, the heart develops ventricular hypertrophy that progressively decompensates and leads to heart failure. miRNAs are increasingly recognized as pathogenic factors, clinically relevant biomarkers, and potential therapeutic targets. We identified that mir15a/mir16-1 cluster was negatively correlated with hypertrophic severity in patients with hypertrophic cardiomyopathy. The mir15a/mir16-1 expression was enriched in cardiomyocytes (CMs), decreased in
doi:10.1002/ctm2.242
pmid:33377640
pmcid:PMC7737755
fatcat:sst5k7qdczevzc2uie66x7ln5y