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The mitochondrial DNA constitution shaping T cell immunity in patients with rectal cancer at high risk of metastatic progression
[post]
2021
unpublished
A significant percentage of colorectal cancer patients proceeds to metastatic disease. We hypothesised that mitochondrial DNA (mtDNA) polymorphisms, generated by the high mtDNA mutation rate of energy-demanding clonal immune cell expansions and assessable in peripheral blood, reflect how efficiently systemic immunity impedes metastasis. We studied 44 rectal cancer patients from a population-based prospective biomarker study, given curative-intent neoadjuvant radiation and radical surgery for
doi:10.22541/au.162361415.51409527/v1
fatcat:7qlvy44kd5ewhfmqwzecjzkoiu