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The goal of protein engineering and design is to identify sequences that adopt three-dimensional structures of desired function. Often, this is treated as a single-objective optimization problem, identifying the sequence-structure solution with the lowest computed free energy of folding. However, many design problems are multi-state, multi-specificity, or otherwise require concurrent optimization of multiple objectives. There may be tradeoffs among objectives, where improving one featuredoi:10.1007/s12551-017-0288-0 pmid:28799089 pmcid:PMC5578931 fatcat:soldirukyvhlrou7zqg7q7k5sy