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The epithelium of the urinary bladder must maintain a highly impermeable barrier despite large variations in urine volume during bladder filling and voiding. To study how the epithelium accommodates these volume changes, we mounted bladder tissue in modified Ussing chambers and subjected the tissue to mechanical stretch. Stretching the tissue for 5 h resulted in a 50% increase in lumenal surface area (from ϳ2900 to 4300 m 2 ), exocytosis of a population of discoidal vesicles located in thedoi:10.1091/mbc.01-09-0435 pmid:11907265 pmcid:PMC99602 fatcat:zgujbngiabhldg5dyiyfs2qbri