O6.02 * ANALYSIS OF PD1 AND PD-L1 EXPRESSION IN GLIOBLASTOMA

A. S. Berghoff, B. Kiesel, G. Widhalm, A. Wohrer, K. Dieckmann, M. Filipits, C. Marosi, J. A. Hainfellner, M. Preusser, W. Wick
2014 Neuro-Oncology  
BACKGROUND: Immune checkpoint inhibitors targeting programmed cell death (PD)1 and PD-ligand (L)1 show promising clinical activity in various solid extracranial cancers. Expression of PD1 on tumor infiltrating T lymphocytes and PD-L1 expression on tumor cells were postulated to have predictive value for the response to PD1/PD-L1 targeting immune checkpoint inhibitors. METHODS: 135 specimens of 117 patients (median age 60, range
doi:10.1093/neuonc/nou174.43 fatcat:5vqlji3jvndr5li4vzafrfatn4