Niosomes are basically a novel drug delivery system in which an encapsulated drug is given which improved its bioavailability by releasing the drug at particular site and increasing its therapeutic effect. The drug is release in controlled manner for long period of time and also at particular targeted site. various other drug delivery system such as liposomes, nanospheres, microspheres, etc. liposomes are first system but it shows number of drawbacks such as high cost and stability problems.

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... pare to liposomes, noisome are made of non-ionic surfactant vesicles system and it is better than liposomes. Other additives are cholesterol and charge inducing molecules. Niosomes are amphiphilic in nature they encapsulate both hydrophilic and lipophilic drug and it is affected by various factors during its formation. This review gives information about various methods of preparation, factors affecting, application to treat diseases and limitation. Keywords: Novel drug delivery system, Niosomes, Magic bullet, Non-ionic surfactant.