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Drug Discovery Today
Spontaneous reporting is a crucial component of post-marketing drug safety surveillance despite its significant limitations. The size and complexity of some spontaneous reporting system databases represent a challenge for drug safety professionals who traditionally have relied heavily on the scientific and clinical acumen of the prepared mind. Computer algorithms that calculate statistical measures of reporting frequency for huge numbers of drug-event combinations are increasingly used todoi:10.1016/j.drudis.2008.12.012 pmid:19187799 fatcat:lhpsvzebyvfhjpdtu3b3vrolve