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Alterations in the GAL4 DNA-binding Domain Can Affect Transcriptional Activation Independent of DNA Binding
1998
Journal of Biological Chemistry
The GAL4 protein belongs to a large class of fungal transcriptional activator proteins encoding within their DNA-binding domains (DBD) six cysteines that coordinate two atoms of zinc (the Zn 2 Cys 6 domain). In an effort to characterize the interactions between the Zn 2 Cys 6 class transcriptional activator proteins and their DNAbinding sites, we have replaced in the full-length GAL4 protein small regions of the Zn 2 Cys 6 domain with the analogous regions of another Zn 2 Cys 6 protein called
doi:10.1074/jbc.273.22.13776
pmid:9593720
fatcat:o3reatzrwngkdhmyuc4qqt6mmu