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MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells
[article]
2021
bioRxiv
pre-print
MacroH2A variants have been associated with tumor suppression through inhibition of proliferation and metastasis, as well as their role in cellular senescence. However, their role in regulating the dormant state of disseminated cancer cells (DCCs) remains unclear. Here we reveal that solitary dormant DCCs display increased levels of macroH2A variants in head and neck squamous cell carcinoma PDX models and patient samples compared to proliferating primary or metastatic lesions. We further
doi:10.1101/2021.12.07.471619
fatcat:r74hdmlgfnhtrejcgs64l26wmm