Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells

Penglong Wang, Honggui Zhang, Fuhao Chu, Xin Xu, Jinxuan Lin, Chunxiao Chen, Guoliang Li, Yatao Cheng, Lin Wang, Qiang Li, Yuzhong Zhang, Haimin Lei
2013 Molecules  
A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC 50 = 4.249 µM). Structure-activity relationships are briefly discussed.
doi:10.3390/molecules181013027 pmid:24145795 fatcat:43do46mrhnhonbd4z5jt7xrd2m