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Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells
2013
Molecules
A series of novel ligustrazine-benzoic acid derivatives were synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Combining hematoxylin and eosin staining, we found compound that (3,5,6-trimethylpyrazin-2-yl)methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2yl)methoxy]benzoate (4a) displayed promising protective effect on the proliferation of the injured PC12 cells (EC 50 = 4.249 µM). Structure-activity relationships are briefly discussed.
doi:10.3390/molecules181013027
pmid:24145795
fatcat:43do46mrhnhonbd4z5jt7xrd2m