N-Acetyl-β-D-glucosaminidase in acute myocardial infarction

M. Perwaiz Iqbal, Khawar A Kazmi, Hasan R Jafri, Naseema Mehboobali
2003 Experimental and Molecular Medicine  
A bstract The objective of the study was to investigate whether the lysosom al enzym e, N -Acetyl-β-D-glucosam inidase (NAG ) activity is increased in plasm a of patients with acute m yocardial infarction (AMI) and to determ ine if there is any association betw een plasm a levels of NAG and severity of m yocardial infarction (M I). N A G activity in plasm a w as m onitored in 69 patients with AMI and 135 norm al healthy subjects using a spectrofluorim etric m ethod. A m odified Aldrich ST
more » ... ion score w as used to gauge the severity of MI in term s of size of the infarct. Plasm a NAG levels in AMI patients and norm al healthy subjects w ere found to be 10.92±7.5 U /l and 6.8±2.2 U /l, respectively. These tw o m ean value when com pared by Student's t-test were significantly different P = 0.0001. No statistically significant differences in NAG activity w ere observed in patients in term s of gender, age, location of infarct, tim e from onset of chest pain to blood sam pling in the hospital and size of the infarct.
doi:10.1038/emm.2003.37 pmid:14508067 fatcat:pd36dai6wjdaneuhiungvugfy4