Aim: To assess the effects of pneumoperitoneum on respiratory Mechanics and Hemodynamics in Laparoscopic Cholecystectomy Background: Laparoscopic surgeries have been performed now a day's very frequently. The pneumoperitoneum created in these laparoscopic procedures produces various effects on haemodynamic and respiratory parameters of the patients. Method: 61 patients of ASA grade I and II undergoing laparoscopic cholecystectomy were registered for this study. After induction of GA these

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... ts were ventilated mechanically with tidal volume of 8ml/ kg and RR of 18/min. Haemodynamic (HR, SBP, DBP and MAP) and respiratory mechanics parameter (Peak inspiratory pressure, peak plateau pressure, et CO 2 , spO 2 and end tidal volume) and arterial blood samples (pH, paCO 2 and base deficit/excess) were recorded and analyzed at 30min intervals after creation of pneumoperitoneum with CO 2 . Changes in hemodynamic, respiratory mechanics and ABG were compared between the different time intervals with the base line values. Results: a) Pneumoperitoneum insufflations produced significant increase of heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP). b) It produced significant increase in peak inspiratory pressure (PIP), peak plateau pressure (PPP) and end tidal CO 2 throughout the period of pneumoperitoneum and even after desufflation of pneumoperitoneum. c) Arterial blood gas analysis during the period of pneumoperitoneum showed that PaCO 2 remain increased even after 30min of desufflation of pneumoperitoneum in the recovery room and pH was lowest at 90min after insufflation and remain decreased after 30min of desufflation of pneumoperitoneum in the recovery room.