The present study was conducted in Regional Hospital Hamirpur, Himachal Pradesh, India. A total of 217 adults aged 20-50 (mean age 37.82 ± 8.90 years) of both the sexes were randomly selected. Out of which, 117 were diabetic patients and 100 euthyroid non-diabetic controls group. The concentration of Thyroid stimulating hormone (TSH), triiodothyronin (T3), thyroxin (T4) and insulin were evaluated with direct immune assay. The level of glucose and lipid profile parameters was measured using

more »

... ostic kits. The results showed that the level of TSH was significantly (P<0.0001) increased in both subclinical and clinical hypothyroid diabetic patients in comparison to euthyroid control. T3 and T4 levels were significantly (P<0.0001) decreased in patients as compared to control group. The level of insulin and glucose were significantly increased in hypothyroid patients. The level of high density lipoprotein (HDL) was significantly decreased and level of low density (LDL), triglycerides and very low density lipoprotein (VLDL) increased in subclinical and clinical hypothyroid diabetic patients. We concluded that insulin sensitivity act as a mediator of thyroid induced lipid changes in diabetic patients. INTRODUCTION Thyroid hormones are key regulators of many metabolic process though their effect on protein, carbohydrate and lipid metabolism (Peppa et al., 2010). Hypothyroidism, like obesity is one of the pathophysiological conditions most frequently associated with disorders of lipid metabolism and finally dyslipidemia which is one of the major risk factors of coronary disease (Limbu et al., 2008). The pathophysiology of thyroid dysfunction in diabetes is still unclear; however thyroid antibodies have been suggested to be causative factors (Yasmine et al., 2006). Although there have been several large cross-sectional studies examining the association between thyroid dysfunction and metabolic abnormalities, few have studied type 2 diabetes. Thyroid hormones also influence on various aspects of lipid metabolism including synthesis, mobilization, and degradation (Zhu and Chang, 2010). Overt hypothyroidism is associated with dyslipidemia and increased artheosclerotic vascular disease (Peppa et al., 2011). The aim of the present study was to investigate the role of insulin sensitivity as a mediator of thyroid-induced lipid changes in hypothyroid diabetic patients.