Hypermobility syndrome is a prevalent condition that affects many people. A few researches have suggested that hypermobility syndrome is linked to osteopenia and can impact bone mineral density (BMD). The aim of the present study is to determine BMD, serum vitamin D level and biochemical markers of bone turnover in children with benign joint hypermobility syndrome (BJHS). Methods:This study comprised thirty-seven children diagnosed with BJHS together with thirty-nine children with similar

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... aphic features as controls. All children were subjected to full medical history, nutritional history, clinical examination, laboratory investigations (serum vitamin D, serum osteocalcin, beta cross lap). Assessment of BMD was done by dual energy x-ray absorptiometry (DEXA) scan. Results: Children with BJHS had significant lower serum vitamin D level (P<0.001) although insignificant differences (p>0.05) were detected among the studied groups regarding mean serum osteocalcin and beta cross lap. Among patients with BJHS, the frequency of low BMD was 8.11 % while no patients had osteoporosis. No significant differences (p>0.05) were reported among the studied groups regarding BMD measurements. Conclusion: The current study concluded that vitamin D deficiency is more prevalent in children with BJHS. Raising awareness among rheumatologists and pediatricians of the possibility of this condition among children with BJHS is warranted to early detection and management of such cases.