Does IGF-1 play a role in the biology of ovarian cancer?

Dominika Majchrzak-Baczmańska, Andrzej Malinowski, Ewa Głowacka, Miłosz Wilczyński
2018 Ginekologia Polska  
Objectives: The aim of the study was to investigate serum concentrations of the insulin-like growth factor-1 in women with ovarian cancer and healthy controls, and to compare free IGF-1 levels with selected clinical and pathological parameters. Correlation analysis was used to measure the following: IGF-1 concentration and Ca125; IGF-1 level and the height of the OC patients. Material and methods: The study included 70 patients with OC and 50 healthy controls. Serum concentrations of free IGF-1
more » ... tions of free IGF-1 were measured in all subjects. Routine diagnostic tests (CBC and USG and Ca125) were performed. Results: Significantly higher serum concentrations of free IGF-1 were found in the study group as compared to controls. No statistically significant relationships between IGF-1 serum concentrations and tumor differentiation, histological type, and disease stage were detected. No statistically significant correlations between IGF-1 and Ca125 level or between IGF-1 and growth of OC patients were found. Conclusions: Serum IGF-1 participates in the etiopathogenesis of ovarian cancer in menstruating women, while local synthesis of this factor and other components of the autocrine loop of the IGF-1 system play a greater role in their postmenopausal peers.
doi:10.5603/gp.a2018.0003 pmid:29411341 fatcat:mc4o5me75fdwpmf6i76vmejah4