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The efficient synthesis of thiazolo pyridine 2-amine(3) by reaction of 2-amino pyridine with ammonium thiocyanate(2). The reaction carried out in presence of ceric ammonium nitrate and Dimethyl Sulphoxide as a solvent. The aromatic aldehyde reacts with synthesized compound thiazolo pyridin-2-amine (3) by using catalytic amount of Ni (NO3)2 .6H2O at room temperature. Advantages of this protocol are its very good yields.doi:10.9734/irjpac/2019/v18i330089 fatcat:urz6rklexvbzvbsfbcsdmojspq