The increased incidence of gestational diabetes (GDM), and its negative effect for the mother, and the fetus imposes the need to study the mechanisms which resulting in pregnancy complications development. This study was carried out to study the relationship between (GDM) and some hormones levels (liptin, melatonin, and adropin) in the three semester of pregnant women's, also estimation of (glucose, and lipid) profil). the study included (90) pregnant women divided to three groups (1 st

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... , second semester, and trimester) (30) women for each group. Also the study included (30) non infected women with (GDM). The results showed significant increase of leptin, and adropin(p≤0.05) in first semester comparative with second and third semester and control group. There was significant decrease of melatonin in GDM comparative to control group. The level of lipid profile elevated in (GDM) comparative to non.