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Human blood MAIT cell subsets defined using MR1 tetramers
2018
Immunology and Cell Biology
Mucosal-associated invariant T (MAIT) cells represent up to 10% of circulating human T cells. They are usually defined using combinations of non-lineagespecific (surrogate) markers such as anti-TRAV1-2, CD161, IL-18Ra and CD26. The development of MR1-Ag tetramers now permits the specific identification of MAIT cells based on T-cell receptor specificity. Here, we compare these approaches for identifying MAIT cells and show that surrogate markers are not always accurate in identifying these
doi:10.1111/imcb.12021
pmid:29437263
fatcat:qt3jzab2fvep5d6ci4lbkbkurm