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Potent Inhibition of SARS-Associated Coronavirus (SCoV) Infection and Replication by Type I Interferons (IFN-α/β) but Not by Type II Interferon (IFN-γ)
2004
Journal of Interferon and Cytokine Research
We sought to investigate the anti-severe acute respiratory syndrome (SARS)-associated coronavirus (SCoV) activities of type I (␣ and ) and type II (␥) interferons (IFN) in vitro. Type I IFNs protected cells from cytopathic effects (CPE) induced by SCoV, and inhibited viral genomic RNA replication in FRhk-4 cells (measured by quantitative RT-PCR) in a dose-dependent manner. Intracellular viral RNA copies were reduced 50% by IFN-␣ at a concentration of 25 U/ml and by IFN- at a concentration of
doi:10.1089/1079990041535610
pmid:15296649
fatcat:b37undwc7vbjhf2eiqovus6zr4