In this paper, we report a facile method for the fabrication of type-I collagen-silver nanoparticles ͑Ag NPs͒ multilayered films by utilizing type-I collagen as a medium. These samples were characterized by UV-vis spectra photometer, atomic force microscopy, scanning electron microscopy, and Fourier transform IR spectrum. Experimental results show that collagen molecules serve as effective templates to assemble Ag NPs into multilayer films. These samples exhibit high surface-enhanced Raman

more »

... ering ͑SERS͒ enhancement abilities. For example, EF͑ cc ͒ ͑EF means enhancement factor͒ at 1592 cm −1 in the SERS spectrum of 4-aminothiophenol on seven-layered substrates was calculated to be 1.81ϫ 10 5 , which is larger than that reported in several literatures. The EFs increased as the layer number of multilayer films increases.