Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

Nathalie Picollet-D'hahan, Agnieszka Zuchowska, Iris Lemeunier, Séverine Le Gac
2021 Trends in Biotechnology  
Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which human health research is conducted. After briefly reviewing the need for comprehensive multiorgan models with a systemic dimension, we highlight scenarios in which multiorgan models are advantageous. We next overview existing multi-OoC platforms, including integrated body-on-a-chip devices and modular approaches involving interconnected organ-specific modules. We highlight how multi-OoC models can
more » ... e unique information that is not accessible using single-OoC models. Finally, we discuss remaining challenges for the realization of multi-OoC platforms and their worldwide adoption. We anticipate that multi-OoC technology will metamorphose research in biology and medicine by providing holistic and personalized models for understanding and treating multisystem diseases.
doi:10.1016/j.tibtech.2020.11.014 pmid:33541718 fatcat:osvlgjcckna63l7ikr5mzmnmha